Post a pic that makes you LOL

[Knundrm]

Man, this version really hits home with me!

 

[WizardOfBoz]

What's the difference between initial half-life and terminal half-life? What is terminal half-life? Since "half-life", in every context of which I'm aware, is the time for a thing being measured to decrease by half, so it is inherently not terminal.

Ok, recall that I said that the info was for pharmacologists... But here goes.

;tldr version: the drug gets absorbed by the tissues and leaks out more slowly than the clearance rate from the blood.

If you plot blood concentration of a drug vs time using a semilog plot (log of concentration vs linear time) you often observe a linear increase, then the concentration maxes out and the data decrease linearly. If this happens you can make the argument that the increase shows that the drug was absorbed due to mass action (there's a half life in the gut) and then the drug clears out due to mass action (there's a half life in the blood). Mass action is:

rate of drug clearance (in gut or blood) = ln(2)/(half life) * mass of drug (in gut or blood)

This is a pretty simple case. Sometimes (often) drugs distribute from the blood into the tissue. When this happens, you'll see a "kink" in the drug log concentration vs time curve. The data decrease pretty fast initially as the blood is cleared. Then the drug leaks out of the tissues more slowly.

This is apparently what happens in propofol. It goes in and gets absorbed into the tissue while it clears from the blood. Then the drug in the tissue leaks out mroe slowly. Because there are two slopes, you can calculate two half-lives.

For the layperson who is getting propofol, one just needs to know that its effects clear pretty quickly.

 

[kuririn]

 

[jqavins]

Ok, recall that I said that the info was for pharmacologists... But here goes.

;tldr version: the drug gets absorbed by the tissues and leaks out more slowly than the clearance rate from the blood.

If you plot blood concentration of a drug vs time using a semilog plot (log of concentration vs linear time) you often observe a linear increase, then the concentration maxes out and the data decrease linearly. If this happens you can make the argument that the increase shows that the drug was absorbed due to mass action (there's a half life in the gut) and then the drug clears out due to mass action (there's a half life in the blood). Mass action is:

rate of drug clearance (in gut or blood) = ln(2)/(half life) * mass of drug (in gut or blood)

This is a pretty simple case. Sometimes (often) drugs distribute from the blood into the tissue. When this happens, you'll see a "kink" in the drug log concentration vs time curve. The data decrease pretty fast initially as the blood is cleared. Then the drug leaks out of the tissues more slowly.

This is apparently what happens in propofol. It goes in and gets absorbed into the tissue while it clears from the blood. Then the drug in the tissue leaks out mroe slowly. Because there are two slopes, you can calculate two half-lives.

For the layperson who is getting propofol, one just needs to know that its effects clear pretty quickly.

Thanks. Makes perfect sense.

 

[kuririn]

 

[Mugs914]

and Fag meant...

A cigarette...

 

[MALBAR 70]

 

[MALBAR 70]

A cigarette...

I thought it was what this guy was carrying ...

 

[MALBAR 70]

 

[dr wogz]

I thought it was what this guy was carrying ...

View attachment 646439

That's Led Zeppelin's 4th album.. AKA 'Zoso' / 4 symbols

 

[MALBAR 70]

 

[MALBAR 70]

That's Led Zeppelin's 4th album..

Yes it is, a Mr. Lot Long

 

[Knundrm]

View attachment 646438

 

[MALBAR 70]

 

[MALBAR 70]

 

[kuririn]

Should have put a rocket with laundry deployed under that sign.

 

[WizardOfBoz]

 

[Huxter]

Halloween decoration:

 

[Dwatkins]

 

[Zeus-cat]

I've had the rectal camera without anesthetic for a partial colonoscopy(1/3 of the way) Trust me. You want the anesthetic......It's very unpleasant.
Although, you can drive straight afterwards.......

Honestly, I think I would be swerving all over the place and not staying in my lane

 

[SolarYellow]

View attachment 646445

That's going to be a bad idea in a few more years. Like the middle-aged guys with a ring of hair plugs where their hairline used to be.

 

[OverTheTop]

I have friends who have a nice heavy-duty doormat at their front door that says "Leave". Not Welcome, Leave. I tried to buy it from them, was greeted with a hard No. They had purchased so many years prior (well before the pandemic) they couldn't remember where or how much they paid. Man, what I would give . . . .

I saw one for sale that said:
Don't Stop
Be Leaving

 

[KenECoyote]

I found this old email yesterday (circa 2015). Math to get 60% seems off.

 

[Cape Byron]

 

[WizardOfBoz]

I have friends who have a nice heavy-duty doormat at their front door that says "Leave". Not Welcome, Leave. I tried to buy it from them, was greeted with a hard No. They had purchased so many years prior (well before the pandemic) they couldn't remember where or how much they paid. Man, what I would give . . . .

I was tempted to use let me google that for you (lmgtfy.com). But you can but it from Amazon and other places:
https://www.amazon.com/Doormat-Housewarming-Outdoor-Kitchen-Bedroom/dp/B0C6JVGTNK?th=1

 

[Tech 68]

 

[Bravo52]

 

[Cape Byron]

 

[Cape Byron]

 

[les]