Having been to Italy many times, including that region, I am guessing that having the ability to predict an earthquake if possible would certainly allow them to begin to evacuate but not likely in time. Their roads and alleys are narrow, the homes are very close and in a lot of cases the villages, towns, etc. are built on a design based on fortification, not transportation/evacuation.
That aside although their structures are very charming and in most cases much older than what we have in North America, they are not quake proof and just fall apart during these larger quakes.
I am not an engineer but I would guess that on the technical side of quake proofing a structure these may be a bit challenging. From an architectural side I am also guessing that they may be challenging from the perspective of maintaining the integrity of their charm.
Then there is the financial side of such an undertaking.