More info on the preprint that came out in Dec. on the Itajai study:
https://www.factcheck.org/2022/03/s...support-ivermectin-as-treatment-for-covid-19/Politifact calls the study flawed.
Excerpt:
Insufficient Evidence from Flawed Study
The second
study Campbell presents in his video is a prospective, observational study done in the Brazilian city of Itajaí. Its authors include Dr.
Pierre Kory, one of the
strongest advocates of ivermectin in the U.S., and researchers in Brazil, Canada and Colombia — some of them also part of Kory’s pro-ivermectin nonprofit, called the
Front Line COVID-19 Critical Care Alliance. The study concludes that the use of ivermectin reduced infections by half and reduced COVID-19 mortality and hospitalizations by 70% and 67%, respectively.
“70% reduction in mortality in this study. I mean, this is just huge. And this is with a tiny dose of ivermectin every fortnight acting as a prophylactic, you know, why are people not talking about this?” Campbell says in his video. “The evidence just seems so powerful, present and overwhelming. I mean, 70%, how do you argue with a number like that?”
But the study is not a randomized, double-blind, placebo-controlled clinical trial, and it has multiple limitations.
Health Feedback fact-checked stories published by the Gateway Pundit, Zero Hedge and the Blaze about an
earlier draft of the study that was posted as a preprint in December.
“The study contained multiple methodological flaws that call the reliability of its conclusions into question. For example, there are indications that many people assigned to the ivermectin treatment group didn’t take the drug consistently, or stopped taking it after a while. It is therefore unclear whether any observed effect in this group can be reliably attributed to ivermectin treatment,” Health Feedback concluded.
In a
Twitter thread on Dec. 15, epidemiologist
Gideon Meyerowitz-Katz detailed some of the study’s problems, including conflicts of interest and lack of controls for important confounders, such as variables that could increase the risk of getting COVID-19.
The study was then peer-reviewed and
published on Jan. 15 in Cureus, an open access online medical journal that allows researchers to publish studies for
free and faster than the traditional peer-reviewed journals — 11 days in this case. But some of the problems remain, as PolitiFact.com
explained.
The study analyzed data of a citywide COVID-19 prevention program using ivermectin in Itajaí, Brazil, from July to December 2020, when vaccines were not available. The whole population of the city was offered ivermectin, to be taken for two consecutive days every 15 days. Out of 159,561 residents, 113,845 used ivermectin and 45,716 did not. But according to a
statement released by the city of Itajaí in January 2021, the numbers of voluntary users fell with time — 138,216 took the first dose; two weeks later 93,970 took the second and third doses, and only 8,312 took the fourth and fifth. “That is, there was no biweekly continuity of the use of ivermectin, as recommended,” the statement said.
A list of the authorized studies in Brazil using ivermectin as treatment for COVID-19 — provided to the Brazilian fact-checking coalition
Comprova by the Brazilian National Research Ethics Commission — said the study “was registered with a sample of 9,956 participants.”
As we said, results of multiple large clinical trials on the safety and efficacy of the use of ivermectin to treat COVID-19 will be available in the coming months. They will provide a more definitive answer as to whether ivermectin is beneficial, or not, in treating COVID-19 patients. But for now, studies haven’t found the drug to be beneficial, and health officials have warned people not to self-medicate.