It is often tough. I wash down with mild detergent, wipe with acetone (standard polypropolene is not damaged by acetone), sand well with 100 grit, wipe with acetone again. Then when you are ready to prime, first spray with
Duplicolor Adhesion Promotor, wait 3 to 5 minutes and then proceed with filler-primer. Then do the typical prime/sand (180 to 220 grit) cycle until you are happy it is smooth enough, then apply a white base primer. I might do a couple rounds of sanding (320 or 400 grit) of that and then apply one to three color coats fairly quickly with very light progressing to heavy coverage. I don't sand between color coats if nothing gets into the mix (bugs, dust, etc.). If they do, I will typically wait until dry 24+ hours, then do a light sanding concentrating on the blemish and then do another light, then full color coat. Following the above procedure, for the most part, I haven't had nosecone chipping on plastic or fiberglass for about five years (before that it was hit/miss).