I have flown both 75 and 98mm CF MD rockets, mostly using a tower. I have also used the aluminum conformal rail guides. As Steve says, they can be torqued off the rocket if things go 'sideways' during loading, which I've seen happen. But I've found that if you properly prep the surface of the CF (degrease and sanded to a water break) as well as the aluminum guide, and use JB Weld, they can form a very strong bond. I've done some destructive testing on a crashed rocket and was surprised at the strength of the guide. And since you know in advance if using a guide, you can take extra care when loading the rocket on the rail to prevent issues.
For what it's worth, in my experience, most of the failures of the conformal guides has been when the nose of the rocket was lifted too high during loading and pulled the bottom guide off the rocket. You can help that by having some thin pieces of wood or similar material that you can put in between the rocket and the rail and then basically keep the rocket against them as you slide it down. That makes it a lot easier to keep the correct spacing. Even a folded rag works well. Also, you should have plenty of helpers loading the rocket and one person who is eye level with the rail to guide everyone. And it sounds dumb, but use simple commands like 'nose towards my side', or 'nose closer to the rail', so there is no confusion as what to do. Talk over the loading procedure with all involved.
As an aside, one downside to a tower I've experienced is 'tower rash', or long scratches along the length of the rocket where it is in contact with the a tower rail. For that reason I use the Jim Jarvis method (at least that's who I learned it from) of coating the CF with a very thin layer of laminating epoxy, or, I'll just leave it naked. Either way, a little wet sanding after the flight and it looks pretty good.
Good luck,
Tony
EDIT: We also have a dedicated 'fin holder' - they keep hold of the fins as it slides down the rail to keep it vertical, and then are responsible for keeping it stable while it's being raised.