Coronavirus: What questions do you have?

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I thought I responded to this. The epidemiologists have not found anything, yet.

Currently, there has not been a large nationwide epidemiology study to date. We have no idea how many have many people in US have been infected because a good study had yet to be completed. The problem with infection rates is we have limited ability to estimate the length of protection from a live infection.
Thanks Chuck . Have a safe weekend, sir!
 
I worked the last 72 hours straight to get the next 96 hours off. I evaluated and tested over 100 and reviewed in the immunizations of 0ver 700 patients. I hope this is done, but I have my doubts. Last summer it slowed and then bam.
 
Moved this from Mask rant


I wear a mask to protect you from me. I work around COVID every day. I personally could not care if you wear a mask, but stay 6 feet away from me. That I will enforce.

I remember (gad it seems like a loooooong time ago) you correcting me, telling me vaccines don’t necessarily prevent infections, they prevent or reduce SYMPTOMATIC infections.

that said, has there been any reliable documentation of a vaccinated previously UNINFECTED person contracting an ASYMPTOMATIC infection and transmitting it to an UNVACCINATED person producing a SYMPTOMATIC infection? (Just typing that starts to sound like @JAL3 ‘s Rube Goldberg sadly incomplete lander build thread!)

I understand the mRNA vaccines specifically target the spike protein and ONLY the spike protein. Is there a specific component of Covid that J and J targets? And could it be that the spike protein is so critical to the Covid virus that the mutations that significantly change the spike protein (to the point it isn’t recognized by the antibodies produced in mRNA vaccinated people) are less successful than their fellow virions and don’t propagate?

I guess I am selfish. I am vaccinated Pfizerx2 and still wear a mask in stores (usually two), I am doing it to protect myself (even if minimal added protection) from what (by the above stats) is a significant U.S. population that has DECLINED a free vaccination, is wandering around WITHOUT a mask potentially both contracting and SPREADING the latest and greatest Covid variants, as I fear eventually one of these variants will be completely resistant to my two Pfizer shots. I neither want to chance getting this nor taking the gift that keeps on giving to my wife at home, also vaccinated.

Chuck, if you can talk about it, do you think the next generation vaccine, particularly if mRNA, will have a SINGLE protein target or MULTIPLE protein targets?

any estimate on what percentage of U.S. population is left that has NEITHER had Covid NOR been vaccinated?

any U.S. reports of documented Covid survivors (had documented virus and recovered.) who have not been vaccinated contracting the new variants?

there is all this panic about the vaccine causing possible myocarditis. But wait a minute. Covid infection ITSELF can cause myocarditis

source

https://www.health.harvard.edu/blog/covid-19-and-the-heart-what-have-we-learned-2021010621603Inflammation of the heart muscle, called myocarditis, typically occurs only in patients with advanced COVID-19 disease. Myocarditis can result from direct heart invasion by the virus itself, or more commonly by inflammation caused by cytokine storm. When this occurs, the heart may become enlarged and weakened, leading to low blood pressure and fluid in the lungs. While this severe form of myocarditis is rare, recent studies have suggested that a milder form of heart muscle inflammation may be much more common than previously recognized. A recent study showed that asymptomatic heart inflammation was seen on magnetic resonance imaging in up to three-quarters of patients who had recovered from severe COVID-19.

It seems entirely possible that the small fraction of vaccine recipients who got myocarditis from the vaccine (almost certainly an autoimmune reaction) would have been just as likely (possibly more) to get it from actual Covid infection (in addition to all the wonderful other things Covid offers the human body.). I think I remember you (a long time ago but thankfully in the same galaxy) discussing Covid 19 myocarditis in the younger active duty population well before the vaccines were out.

if mRNA vaccine generates cells to make spike proteins that provoke antibodies to spike proteins which in susceptible individuals rarely provokes autoimmune myocarditis, it seems highly likely the same cascade would occur with ACTUAL spike proteins created by active Covid infection as well.
 
Just tested myself and my youngest at home with a Cue Health EUA device ( everybody's fine, just confirming before going to a routine doctor visit ). Pretty cool.

One possible future is that I could just have something like this at home & whenever someone gets the sniffles > 48 hrs we just slot in a test, teledoc does a quick consult, meds in tomorrow's mail.

EDIT: opened the disposable cartridge, about what I expected in there.
 

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I seem to remember myocarditis and pericarditis are not considered life-threatening. They are possible side-effects of the Pfizer vaccine which I am scheduled to get on August 8th. It has not put me off. Covid is life-threatening.
 
I had zero side effects from the two Pfizer jabs, other than the expected sore arm the next morning.
The soreness disappeared by the afternoon.
I did feel sleepy and took a nap the day after the second jab.
But that might just be normal. 😁
 
that said, has there been any reliable documentation of a vaccinated previously UNINFECTED person contracting an ASYMPTOMATIC infection and transmitting it to an UNVACCINATED person producing a SYMPTOMATIC infection? (Just typing that starts to sound like @JAL3 ‘s Rube Goldberg sadly incomplete lander build thread!)
I don't have data on this.

Is there a specific component of Covid that J and J target?
Great question. J&J is based on adenovirus. I am not an expert but my understanding is that it uses double-stranded DNA to do the same as the mRNA. I have never given on of these vaccines because it is not available to our facilities

And could it be that the spike protein is so critical to the Covid virus that the mutations that significantly change the spike protein (to the point it isn’t recognized by the antibodies produced in mRNA vaccinated people) are less successful than their fellow virions and don’t propagate?
You are on the right track. It could both makes it less infectious and less likely to be recognized. It could also do one or the other.

I guess I am selfish. I am vaccinated Pfizerx2 and still wear a mask in stores (usually two), I am doing it to protect myself (even if minimal added protection) from what (by the above stats) is a significant U.S. population that has DECLINED a free vaccination, is wandering around WITHOUT a mask potentially both contracting and SPREADING the latest and greatest Covid variants, as I fear eventually one of these variants will be completely resistant to my two Pfizer shots. I neither want to chance getting this nor taking the gift that keeps on giving to my wife at home, also vaccinated.
I kind of agree with you. The creator gave you a brain. If you do not take vaccines, it is Darwinism's ability to weed out those who refuse a vaccine. Then again, they could say the same about us. Time will tell.

Chuck, if you can talk about it, do you think the next generation vaccine, particularly if mRNA, will have a SINGLE protein target or MULTIPLE protein targets?
Yes. The ones that I have seen research on are mRNA vaccines. We will probably use a combination for the boosters.

any estimate on what percentage of U.S. population is left that has NEITHER had Covid NOR been vaccinated?
No. There are not good population studies to date.

any U.S. reports of documented Covid survivors (had documented virus and recovered.) who have not been vaccinated contracting the new variants?
Deaths are rare. Data is sparse.

there is all this panic about the vaccine causing possible myocarditis. But wait a minute. Covid infection ITSELF can cause myocarditis

I think that is the exact point I would make. Myocarditis from covid is rarely fatal. You do need to be smart. You can increase your odds of sudden cardiac death by running a marathon weeks after covid.
 
Gentle ping on this just to keep it on the radar.

Also, new(ish) question:

Are there any good resources discussing extent of known cases of Covid, suspected extrapolated infections, and the overlap with vaccination demographics?

So, we know of about 34 Million US cases. How many infections do we currently think there have been? In the old days at the start, infections were like 10:1 over cases. Do we have a model of historical cases versus infections since the start of this? So, there are 34 M cases and suspected XXX M infections total.

And current estimates: There are currently ~13k new infections each day and we think there are YY k new infections each day.

If the pool of infected folks that have some level of natural immunity is more like 100M rather than the known 34M cases that would be interesting data, also how do we think it meshes with the vaccination demographics...

Thanks Chuck!
I thought I responded to this. The epidemiologists have not found anything, yet.

Currently, there has not been a large nationwide epidemiology study to date. We have no idea how many have many people in US have been infected because a good study had yet to be completed. The problem with infection rates is we have limited ability to estimate the length of protection from a live infection.


Found it!!

Check the graphs here: https://www.cdc.gov/mmwr/volumes/70/wr/mm7023e2.htm#F2_down

Main article here: https://www.cdc.gov/mmwr/volumes/70/wr/mm7023e2.htm

Figure showing age ratios:
1626138292302.png1626138292302.png
 
Anybody got data on
1. What percentage of U.S. population is NEITHER vaccinated NOR previously infected? (caveat previous infection may not protect from new variants as well as the vaccines.). Seems like one way or the other, at some point EVERYBODY still living will either have been vaccinated OR have survived the infection and become immune.

2. What percentage of current U.S. cases (reportedly 99% unvaccinated) are RECURRENT cases? (had original Covid strain infection, now get reinfected with one of the variants)
 
Chuck: is there some official site that breaks down the various adverse events seen in VAERS by category (death, Bell's Palsy, GBS, etc.) and for each vaccine states the rate seen and the baseline rate in the population involved, and thus the increase in risk? The idea is to demonstrate just how minimal those risks are. I'm dealing with so many people on social media that are convinced every death in VAERS is caused by the vaccine when it's really just a handful, but I haven't yet found an official or at least learned (JAMA/NEJM) analysis of the data that ties it up in a neat bow.
 
Chuck: is there some official site that breaks down the various adverse events seen in VAERS by category (death, Bell's Palsy, GBS, etc.) and for each vaccine states the rate seen and the baseline rate in the population involved, and thus the increase in risk? The idea is to demonstrate just how minimal those risks are. I'm dealing with so many people on social media that are convinced every death in VAERS is caused by the vaccine when it's really just a handful, but I haven't yet found an official or at least learned (JAMA/NEJM) analysis of the data that ties it up in a neat bow.

Not a reliable site. VAERS is self report with no confirmation.
 
6000 deaths or so have happened after COvID. “FDA requires healthcare providers to report any death after COVID-19 vaccination to VAERS, even if it’s unclear whether the vaccine was the cause.”
 
Here’s the BS I’ve personally heard people say about the virus, it’s a hoax, they’re infringing on our rights, it has a 1% or less death toll.
I am active on my local Nextdoor, posting factual information; many of my questions here are to get good links to share.

The Nextdoor thread I'm currently in has devolved to conspiracy theories saying all the VAERS reports are caused by the vaccine, and just recently several folks are on about how the vaccine caused their family members to become magnetic, and how they need to go on a detox or chelation or some insane thing.
 
I am active on my local Nextdoor, posting factual information; many of my questions here are to get good links to share.

The Nextdoor thread I'm currently in has devolved to conspiracy theories saying all the VAERS reports are caused by the vaccine, and just recently several folks are on about how the vaccine caused their family members to become magnetic, and how they need to go on a detox or chelation or some insane thing.
The local and state governments spent tons of money on a alternate care facility in Memphis that they knew would never open because of lack of personnel to run it. So much money wasted, pathetic.
 
I am active on my local Nextdoor, posting factual information; many of my questions here are to get good links to share.

The Nextdoor thread I'm currently in has devolved to conspiracy theories saying all the VAERS reports are caused by the vaccine, and just recently several folks are on about how the vaccine caused their family members to become magnetic, and how they need to go on a detox or chelation or some insane thing.

I am deeply disappointed in the Moderna vaccine. Did I get a third arm? No. 5G reception? Nope. And now I hear I was supposed to become magnetic and didn't get that either? WTF man?! I guess I shoulda gotten Pfizer.
 
I also had the Pfizer shot. No superpowers or improved 5g reception. I was also told that my injection site would glow due the presence of luciferin (enzyme in fireflies, not some fluid emitted from Satan himself like the pamphlet said). That didn't happen either.
 
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